基于中药组分的中药多元释药系统的构建

Construction of multiple drug release system based on components of traditional Chinese medicine

随着中药制剂现代化发展,中药新剂型的研究已成为当前中药领域的研究热点。由于中药多成分复杂性、物质基础不明确等问题,至今还没有形成科学的中药现代剂型研究系统思路。现代中药制剂必然要考虑中药多组分的性质和多环节多靶点的整体作用特点。作者提出针对中药组分的性质和作用特点,采用多元化的制剂技术和层次化的释药方式构建中药多元释药系统。该文深入阐述了中药多元释药系统构建思路、理论依据、制备技术和评价体系以及面临的问题及解决策略,以期构建以提高中药组分生物利用度为核心的中药多元释药系统理论与技术平台,为中药制剂提供一种新的模式。

With the development of the modernization drive of traditional Chinese medicine（TCM） preparations,new-type TCM dosage forms research have become a hot spot in the field.Because of complexity of TCM components as well as uncertainty of material base,there is still not a scientific system for modern TCM dosage forms so far.Modern TCM preparations inevitably take the nature of the multi-component and the general function characteristics of multi-link and multi-target into account.The author suggests building a multiple drug release system for TCM using diverse preparation techniques and drug release methods at levels on the basis the nature and function characteristics of TCM components.This essay expounds elaborates the ideas to build the multiple traditional Chinese medicine release system,theoretical basis,preparation techniques and assessment system,current problems and solutions,in order to build a multiple TCM release system with a view of enhancing the bioavailability of TCM components and provide a new form for TCM preparations.