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药物性脂肪肝 被引量：3

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摘要 药物性脂肪肝的发生率不断增加。药物可引起微泡性或大泡性肝细胞脂肪变。药物性肝损伤所致肝细胞变性及坏死程度不等,取决于药物的种类。本文讨论了药物性脂肪肝的组织病理学类型、发病机制、临床表现、诊断及防治方法。
作者 李晶莹 陆伦根
机构地区 上海交通大学附属第一人民医院消化内科
出处 《实用肝脏病杂志》 CAS 2012年第4期284-285,共2页 Journal of Practical Hepatology
关键词 脂肪肝 药物 防治
分类号 R575.5 [医药卫生—消化系统]
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参考文献18

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同被引文献54

  • 1倪鸿昌,李俊,金涌,臧红梅,彭磊.大鼠实验性高脂血症和高脂血症性脂肪肝模型研究[J].中国药理学通报,2004,20(6):703-706. 被引量：170
  • 2李玉红,张震之,段卫华,徐宗佩,张伯礼.小鼠急性脂肪肝模型的建立及脂肝清作用观察[J].天津中医学院学报,2005,24(1):13-16. 被引量：9
  • 3孙要武,何宝国,吴嘉慧,李省三.大鼠脂肪肝实验模型的建立[J].齐齐哈尔医学院学报,2005,26(4):361-362. 被引量：10
  • 4陈卫华,郭松超.肝脏损伤动物模型及观察指标研究现状[J].广西医科大学学报,2007,24(1):156-158. 被引量：15
  • 5Ni H C,Li J,Jin Y,et al.The experimental animal model of hypedipiemia and hypedip idemic fatty liver in rats[J].Chin PharmacolBull,2004,20 (6):703-706.
  • 6Suk KT,Kim DJ.Drug-induced liver injury:present and future[J].Clin Mol Hepatol,2012,18(3):249.
  • 7Corsini A,Bortolini M.Drug-induced liver injury:the role of drug metabolism and transport[J].J Clin Pharmacol,2012,53(5):463.
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  • 9Ingawale DK,Mandlik SK,Naik SR.Models of hepatotoxicity and the underlying cellular,biochemical and immunological mechanism(s):A critical discussion[J].Environ Toxicol Pharmacol,2013,37(1):118.
  • 10Chen IS,Chen YC,Chou CH,et al.Hepatoprotection of silymarin against thioacetamide-induced chronic liver fibrosis[J].J Sci Food Agric,2012,92(7):1441.

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实用肝脏病杂志
2012年 第4期

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