肝窦病变对慢性乙型肝炎肝脏微循环障碍的影响

The pathological changes of hepatic sinusoids in patients with chronic hepatitis B

目的研究肝窦病变对慢性乙型肝炎肝脏微循环障碍的影响。方法采用肝窦形态体视学方法测定肝窦数目、肝窦总面积、总周长、平均直径等指标,并采用透射电镜观察肝脏微循环结构改变特点。结果慢性乙型肝炎重度患者肝窦总面积、总周长、平均直径增大(P<0.05),肝窦内皮细胞窗孔减小、基底膜形成、Disse腔胶原沉积增加(P<0.05),但肝窦数目减少(P<0.05);慢性乙型肝炎轻度和中度患者肝窦内皮细胞中WP小体检出率分别为53.5%和59.1%,而在重度患者仅为12.9%。结论肝窦病变在慢性乙型肝炎肝脏微循环障碍中起关键作用。

Objective To study the pathological changes of hepatic sinusoids in patients with chronic hepatitis B. Methods The number,total area,total perimeter and average diameter of hepatic sinusoids were detected by stereology under transmission electron microscope. Results The total area,total perimeter and average diameter of hepatic sinusoids in patients with chronic hepatitis B of severe degree increased,the basal lamina formed,and collagen deposited in Disse＇s space;WP bodies were detected in 53.5% and 59.1% in SECs in patients with CHB of mild and moderate degree,respectively,while that was only in 12.9% of patients with CHB of severe degree. Conclusion The pathological changes of hepatic sinusoids play a key role in the microcirculation disturbance of liver in patients with chronic hepatitis B.