血链球菌与疾病研究进展

Advance in Streptococcus sanguis and Diseases

血链球菌是早期定植在口腔内的细菌之一,也是口腔内的常驻菌。血链球菌作为牙周有益菌对大多数牙周可疑致病菌具有拮抗作用。其主要机制为产生过氧化氢和血链素。由于各种原因进入血液循环后可引起感染性心内膜炎,主要机制为血链球菌的表面抗原使血小板产生黏附、聚集,其在血小板表面的结合位点在血小板膜糖蛋白Ib附近。单核细胞在血链球菌的刺激下表达大量的组织因子,激活外源性凝血途径形成血栓。

Streptococcus sanguis （Ss） is one of the bacteria planted in the oral cavity in early stage, it is also the resi- dent bacteria in oral cavity. As a beneficial periodontal bacterium, it plays antagonism against the most of suspicions pathogenic bacteria, The main mechanism is to produce hydrogen peroxide and sangui-streptocin. After it enters into the blood circulation on various accounts, it could cause infective endocarditis. The main mechanism is the platelet aggregation caused by Ss＇ surface antigen makes the platelet to adhere and aggregate. The combining point of the platelet surface is near glucoprotein Ib of platelet membrane. Under the stimulation of Ss mononuclear leucocyte ex- presses lots of tissue factor and activate the exogenous blood-coagulation pathway to form thrombus.