冠心病糖代谢异常患者血浆Ghrelin水平及临床意义

Plasma ghrelin level in patients with coronary heart disease with abnormal glucose metabolism and its clinical significance

目的:探讨冠心病糖代谢异常患者血浆胃饥饿素(Ghrelin)水平及其相关临床意义。方法:将纳入研究对象依据相关检验及检查结果分为正常对照组、冠心病组(冠心病糖代谢正常组和冠心病糖代谢异常组)、单纯糖代谢异常组。收集所有入选对象入院第2天清晨空腹血样,采用ELISA方法同批检测血浆Ghrelin水平。结果:①冠心病组及单纯糖代谢异常组血浆Ghrelin水平均显著低于正常对照组。②冠心病糖代谢异常组血浆Ghrelin水平显著低于冠心病糖代谢正常组及单纯糖代谢异常组。③析因分析结果显示:冠心病与糖代谢异常在对血浆Ghrelin水平影响方面不存在交互作用。然而,糖代谢异常比冠心病对血浆Ghrelin水平的影响更明显。结论:冠心病糖代谢异常患者血浆Ghrelin水平显著下降,且糖代谢异常对Ghrelin的影响更明显。

AIM： To study plasma ghrelin level distribution in patients with coronary heart disease （CHD） with abnormal glucose metabolism and to discuss its clinical significance. METHODS： According to laboratory examination results, subjects were divided into control group, coronary heart disease with normal glucose metabolism group, coronary heart disease with abnormal glucose metabolism group and abnormal glucose metabolism group. Fasting blood samples were collected the morning after admission with EDTA-2K anticoagulation tubes. Blood samples were then transferred to centrifuge tubes containing aprotinin and were centrifuged to extract plasma for cryopreservation. All blood plasma ghrelin levels were tested with ELISA. RESULTS： Compared with those in control group, ghrelin levels were significantly reduced in the group with CHD with normal glucose metabolism, group of CHD with abnormal glucose metabolism and group with abnormal glucose metabolism. Compared with those in the group of CHD with normal glucose metabolism, levels of ghrelin were significantly reduced in patients with CHD with abnormal glucose metabolism. Using CHD and abnormal glucose metabolism as two factors affecting plasma ghrelin levels, factorial analysis showed no interaction （P = 0. 453 ）. However, the group of abnormal glucose metabolism had more effect on plasma ghrelin levels than CHD. CONCLUSION： Ghrelin levels decreased significantly in patients with CHD with abnormal glucose metabolism and abnormal glucose metabolism has more obvious effects on ghrelin levels.