银杏叶提取物在慢性阻塞性肺疾病急性加重期的应用研究

The Effect of Ginkgo Biloba Extract on Acute Exacerbation of Chronic Obstructive Pulmonary Disease

目的:探讨银杏叶提取物治疗慢性阻塞性肺疾病(COPD)急性加重期患者的临床疗效及抗炎作用。方法:80例患者随机分为观察组和对照组各40例,均给予常规治疗,观察组加用银杏叶提取物,疗程2周,观察两组患者治疗后的临床疗效,以及治疗前后血清肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、一氧化氮(NO)及血管假血友病因子(vWF)水平变化。结果:观察组患者总有效率为92.50%,明显高于对照组的75.00%,差异存在统计学意义(P<0.05);治疗后,两组患者血清IL-8、TNF-α和vWF水平均下降(P<0.05),血清NO水平均上升(P<0.05),但是观察组患者变化幅度更大(P<0.01)。结论:银杏叶提取物可以显著提高COPD急性加重期患者的临床疗效,保护血管内皮细胞的功能和明显抑制气道炎症等作用,值得临床推广应用。

Objective ： To explore the effects of Ginkgo biloba extract in treatment of chronic obstructive pulmonary disease （ COPD ） in patients with acute exacerbation of clinical effects and anti- inflammatory effects. Method： 80 patients were randomly divided into the observation group and the control group, 40 ca- ses in each group. Both groups were given conventional treatment, and the observation group add with Gink- go biloba extract. For 2 weeks, observed the clinical efficacy of the two groups of patients , as well as of serum tumor necrosis factor alpha （TNF alpha） , interleukin 8 （IL-S） ： nitric oxide （NO） and vascular hemo-philia factor （VWF） level. Result： the observation group in the total efficiency was 92.50%, significantly higher than that in control group 75%, a statistically significant difference （ P 〈 0.05 ） ; after the treatment,two groups of patients with serum IL-8, TNF - A and vWF water dropped by an average （P 〈 0. 05）, the serum NO level increased （P 〈 0.05 ）, but the observation group of patients change substantially greater （P 〈 0.01 ）. Conclusion： Ginkgo biloba extract can significantly improve acute exacerbation of COPD patients the clinical efficacy, protecting the vascular endothelial cell function and significantly inhibited the role of airway inflammation, it is worthy of clinical application.