血清YKL-40水平对冠心病合并糖尿病患者的影响研究

Effect of serum YKL-40 on diabetic patients with coronary heart disease

目的观察冠心病合并糖尿病患者血清YKL-40水平及与相关影响因素分析，探讨血清水平对冠心病合并糖尿病患者的影响。方法选取在我科住院治疗患者120例，随机分为正常对照组、单纯冠心病组及冠心病合并糖尿病组，各40例，采取酶联免疫吸附法（Elisa）测定血清YKL-40水平，线性回归相关分析相关影响因素。结果与正常对照组比较，冠心病组及冠心病合并糖尿病组YKL-40水平升高明显，差异有统计学意义（P〈0．05）；冠心病合并糖尿病组YKL-40水平与年龄、FPG、TG、HbAIC等因素存在相关陛，差异具有统计学意义（P〈0．05）。结论YKL-40可作为评估冠脉病变程度及血管壁炎症反应程度的重要指标；年龄、FPG、TG、HbAIC是其影响因素。

Objective To observe serum level of YKL-40 in diabetic patients with coronary heart disease （ CHD ） and analyzed the related influencing factors, and to explore the effect of YKL-40 on those patients. Methods 120 patients which were randomly divided into normal control group, CHD group and group of CHD diabetes mellitus. Enzyme- linked immunosorbent assay （ EIISA ） was used to determine serum YKL-40 levee linear regression analysis was used to analyze the related factors. Results As compared with the normal group, YKL-40 level increased obviously in CHD group and the group of CHD and diabetes, with a statistical significance （ P〈 0.05 ） ; YKL-40 level was related with age, FPG, TG, and HbAIC in the group of CHD and diabetes, with a statistical significance （ P〈 0.05 ）. Conclusions YKL-40 can used as an important indicator for assessing the severity of coronary lesions and the degree of vascular wall inflammatory reaction. Age, FPG, TG, and HbAIC are the influencing factors of YKL-40 level.