9139例非淋菌性尿道炎支原体培养及药敏结果分析

Analysis on mycoplasma culture and drug sensitivity test results in 9139 cases of non-gonococcal urethritis

目的探讨2010年4月至2011年4月本地区非淋菌性尿道炎（NGU）患者解脲支原体（uu）和人型支原体（Mh）感染情况及对抗生素的敏感情况，以指导临床合理用药。方法采用珠海丽珠试剂股份有限公司生产的解脲支原体和人型支原体培养鉴定药敏试剂盒对Uu和Mh进行检测，并对结果进行统计学分析。结果支原体阳性2622例，总感染率为28．7％。uu阳性2300例，占25．2％，Uu、Mh混合型274例，占3．0％，Mh阳性48例，占1。0％。药敏结果对9种抗生素：米诺环素、左氧氟沙星、氧氟沙星、司氟沙星、克拉霉素、阿奇霉素、罗红霉素、交沙霉素、强力霉素的药物敏感率：uu分别为92．0％、13．9％、19．1％、27．4％、62．4％、30．4％、14．7％、89．4％、90．9％，Mh分另0100．0％、50．0％、42．3％、76．9％、3．8％、0．0％、0．0％、100．0％、100．0％，Uu＋Mh混合分别为92．0％、13．9％、9．1％、27．4％、2．6％、2．2％、1．8％、89．4％、90．9％，单纯解脲支原体（Uu）对抗生素的敏感性依次为交沙霉素、米诺环素、强力霉素、克拉霉素。混合感染株（Uu＋Mh）对抗生素的敏感性依次为交沙霉素、米诺环素、强力霉素，单纯人型支原体感染株（Mh）对抗生素的敏感性并列为米诺环素、交沙霉素、强力霉素。结论支原体已成为引起性病的主要病原体之一，药敏试验显示大部分菌株都产生耐药性，混合性感染的耐药性更严重，提示临床应合理使用抗生素，防止耐药株的增加，以提高疗效。NGU患者主要以（Uu、Mh）感染为主，可首选米诺环素、强力霉素、交沙霉素，不宜选用罗红霉素、阿奇霉素、克拉霉素治疗。

ObJective To understand the drug resistance of ureaplasma urealyticum （UU） and mycoplasma hominis （MH）, in order to provide scientific basis for the rational use of antibiotics from April 2010 to April 2011 among non-gonococcal urethritis （NGU） patients in this area. Methods The mycoplasma culture and drug sensitivity test were done using kit produced by Zhuhai Lizhu Co., Ltd. The UU and MH infection levels and the result s of drug sensitivity test were analyzed. Results There were 2622 cases found mycoplasma positive, with a total detection rate of 28.7%, including 2300 strains of UU （25.2%）, 274 strains of UU ＋ MH （3.0 % ）and 48 strains of MH （1.0%）. The susceptibility rates of the 9 kinds of antibiotics： minocycline, levofloxacin, ofloxacin, sparfloxacin, clarithromycin, azithromycin, roxithromycin, josamycin and doxycycline. The drug sensitivity test of 9 antibiotics showed that the sensitivity rates to UU： 92.0%, 13.9%, 19.1%,27.4%, 62.4%, 30.4%, 14.7%, 89.4%, 90.9%, MH： 100.0%, 50.0%, 42.3%, 76.9%, 3.8%, 0.0%, 0.0%, 100. 0%, 100.0%, UU ＋ MH 92.0%, 13.9%, 9.1%, 27.4%, 2.6%, 2.2%, 1.8%, 89.4%, 90.9%. Pure strains of UU sensitivity to antibiotics was followed byjosamycin, minocycline doxycycline, clarithromycin. Mixed infection of strain sensitivity to antibiotics was followed byjosamycin, minocycline, doxycycline. MH to antibiotics was followed by minocycline,josamycin, doxycycline,. Conclusion Mcoplasma is one of the major pathogens of sexually transmited disease. Sensitivity test showed that most strains are resistant to mixed infections more severe drug resistance, suggesting that the clinical use of antibiotics should be reasonable. The urinary tract infections to prevent the increase in drug-resistant strains in order to improve the curative effect. The major pathogeny for NGU patients are （UU and MH）, minocycline, doxycycline,josamycin will be the first choice, inadvisable choice roxithromycin, azithromycin, clarithromycin for NGU patients in this area.