儿童良性黑棘皮病与代谢异常

Childhood benign acanthosis nigricans and metabolic abnormality

目的观察儿童良性黑棘皮病与人体测量指标参数及代谢指标的关系,探讨儿童良性黑棘皮病与代谢性疾病的关系。方法回顾性分析2007年2月至2011年10月于我院诊治的29例良性黑棘皮病患儿的临床资料,以同年龄同性别同民族相匹配的32例正常儿童为对照组。比较两组儿童人体肥胖指标(体重指数、腰臀围比、体脂含量及体脂百分比)及代谢指标(血糖、胰岛素水平、血脂系列)等的不同。结果 29例良性黑棘皮病患儿体重指数、体脂含量、体脂百分数、腰臀围比、空腹血糖及胰岛素水平、甘油三酯均高于对照组(P<0.05),而高密度脂蛋白低于对照组(P<0.05)。29例良性黑棘皮病患儿中,16例存在糖耐量异常,3例确诊为糖尿病(1例1型,2例2型)。结论儿童良性黑棘皮病与肥胖、胰岛素抵抗及血脂异常密切相关。

Objective To observe the relationship of childhood benign acanthosis nigricans to anthropometric and metabolic indexes, with the aim of studying the association between childhood benign acanthosis nigricans and metabolic diseases. Methods A retrospective analysis was performed on the clinical data of 29 children who presented with benign acanthosis nigrieans between February 2037 and October 2011. Thirty-two age-, sex- and ethnic-matched normal children were selected as control group. The two groups were compared according to obesity （body mass index, waist-to-hip ratio, body fat content and body fat percentage） and metabolic indexes （blood glucose, insulin level and blood lipids）. Results Body mass index, body fat content, body fat percentage, waist-to-hip ratio, fasting blood glucose, insulin level and triglyceride in the 29 patients with benign aeanthosis nigricans were higher than in the control group （ P 〈 0.05 ）, but the level of high-density lipoprotein in the 29 patients was lower than in the control group （P 〈0.05 ）. Of the 29 patients, 16 had impaired glucose tolerance and 3 were diagnosed with diabetes （1 case with type 1, two cases with type 2 ）. Conclusions Childhood benign acanthosis nigricans is closely associated with obesity, insulin resistance and dyslipidemia.