自噬与肿瘤

自噬作为一种细胞防御和应激调控的机制,目前成为癌症研究领域的又一热点。在不同种类的肿瘤以及肿瘤发生发展的不同阶段,自噬有抑制和促进两种对立的影响。自噬异常与恶性肿瘤的能量代谢、细胞死亡、炎症反应以及对肿瘤治疗的耐药性等方面都有密切的联系。全面正确地了解自噬可为肿瘤治疗提供一个崭新的思路。

Autophagy as a cellular defense and stress regulation mechanism, has become another hot spot in the field of cancer research, in different stages and types of tumor, autophagy plays two opposing roles： inhibition and promotbn. Abnorrnal autophagy is closely linked with the energy metabolsm,oell death, inflammatory response and treatment resstance of maligmant tumor. Comprehensive understanding of autophagy can provide a new idea, for cancer treatment.