成人念珠菌血症33例临床特点分析

Study on clinical characteristics of candidemia in 33 adult cases

目的研究成人念珠菌血症的流行病学特点,为临床提供诊断和治疗依据。方法对首都医科大学附属北京友谊医院2011年念珠菌血症的成年住院患者进行回顾性分析,调查其病原菌、患者年龄、住院科室、病种分布。结果 33例病人,平均年龄73.3岁,白色念珠菌为最常见菌种(45.5%),念珠菌血症多发生在年龄>65岁老年人,住院病人念珠菌血症发生率为2.45/1 000病人。引起念珠菌血症的病种,以恶性肿瘤最常见(42.4%)。所有菌株对伊曲康唑、两性霉素B、伏立康唑均敏感。结论与年轻人相比,伴有基础疾病的老年人更易患念珠菌血症,念珠菌种类亦不相同,对目前常用的抗真菌药物均敏感。

Objective To study the epidemiological characteristics of candidemia, and to provide evidence for clinical diagnosis and man- agement of candidemia. Methods A retrospective analysis was performed in adult inpatients of this hospital during 2011, in which pathogens, age range of patients, departments of inpatients and distribution of kinds of diseases were studied. Results A total of 33 patients with an average age of 73.3 years old were enrolled in this study, and the most common pathogen was Candida albicans, most patients with candidemia were over 65 years old and its incidence rate was 2.45/1000 inpatients. Cancer is the most common basic disease （42.4%） for inducing candidemia. All iso- lates of Candida albicans were susceptible to itraconazole, amphotericin B and voriconazole. Conclusion In comparison with younger patients, elderly patients with underlying diseases are more susceptible to candidemia. The species of Candida are different, and they are sensitive to cur- rently used antifungal agents.