断奶应激引发仔猪肠道损伤及重建机制研究进展

Advances in Mechanisms of Intestinal Injury Induced by Weaning Stress and Reestablishment in Piglets

肠道的发育与成熟状况是制约幼畜快速生长的关键因素。断奶是仔猪必须经历的一个应激过程,而断奶应激主要的靶点就是仔猪的肠道,特别是小肠的损伤尤为严重。因此,本文从仔猪肠道的形态和结构、肠道消化和代谢相关酶活性、肠道黏膜屏障、肠道功能基因和蛋白的表达及调控、断奶激活的肠道应激信号通路、应激蛋白家族在肠道中的差异表达等多个层面探讨断奶应激导致仔猪肠道损伤及重建的机制。为今后采用各种营养调控手段改善仔猪肠道健康、促进其快速生长提供理论基础和支持。

The status of intestinal development and mature as a key factor is restricting the growth of young animals. Weaning is a stress progress that the piglets had to suffer, and the target of weaning stress is namely the intestinal gut, especially results in the severe damage to small intestine tissue. So the paper explored the mechanisms of intestinal injury and reestablishment induced by weaning stress in piglets from the views of intestinal morphology and configuration, the activities of enzymes associated with the digestive and metabolic functions, intestinal mucosal barrier, the expression of intestinal genes and proteins, stress signaling pathways activated by weaning, the expression and regulation of some stress protein families, and so on. The purpose of this paper was to provide the theoretical basis of improving intestinal health and accelerating fast growth in piglets by the measures of nutritional regulations.