胰岛素泵不同基础量分段法对2型糖尿病的疗效

Effect of setting the base amount of insulin pump on type 2 diabetes at different times

目的:比较3种不同胰岛素泵基础量分段法对2型糖尿病患者血糖控制的疗效优劣。方法:240例使用胰岛素泵治疗的2型糖尿病患者,分为3组,3段组、5段组和24段组各80例。观察3组治疗前后血糖值、血糖达标时间、胰岛素用量及低血糖发生率。结果:治疗前后3组血糖值均下降,差异有统计学意义(P<0.01),3组治疗后血糖值比较差异无统计学意义。与3段组、5段组相比,24段组血糖达标所需时间少,胰岛素用量低,低血糖发生率低,但设置繁杂。5段组胰岛素用量与3段组相似,但达标时间短,低血糖发生率低(P<0.05),且设置简单、方便。结论:5段法设置简单、方便、疗效好。

Objective To observe the clinical effect and safety between three different parts of insulin pump base dose in treated patients with type 2 diabets mellitus. Methods 240 patients with type 2 diabets with insulin pump therapy were randomly divided into 3 groups： 3 parts group, 5 parts group and 24 parts group （80 cases in each group）. The levels of fasting plasma glucose （FPG）, 2 hours postprandial glucose （2hPG）, therapeutic time, insulin dose and the incidence of hypoglucemia were observsed. Results Three groups could decrease blood glucose efficiently （P 〈 0.01）, and there were no significant difference in the level of glucose between three groups after treatment. Compared with 3 parts group and 5 parts group, therapeutic time, insulin dose and the incidence of hypoglucemia in 24 parts group were all decreased （P 〈 0.01）. However, 24 parts were complicatedly setted up, and insulin dose in 5 parts group and 3 parts group were similar. But therapeutic time in 5 parts group was shorter than in 3 parts group. The incidence of hypoglucemia was lower than 3 parts group, and 5 parts were setted up simply. Condusion 5 parts group has the advantages of simple, convenience, and effective.