冠心病患者脂类代谢及炎症因子与代谢综合征关系探究

目的分析代谢综合征对冠心病患者脂类代谢和炎症因子的影响,探讨脂类代谢和炎症因子在冠心病早期治疗诊断的指导意义。方法回顾性分析2010年1月～2011年6月期间住院治疗的冠心病患者168例,分为A组和B组,A组为冠心病患者未达代谢综合征诊断标准病例,B组为符合代谢综合征诊断标准病例,检测血清中CRP、IL-6、TNF-α、TC、TG、LDL-c、HDL-c和脂联素等指标浓度。结果冠心病患者代谢综合征发病率为46.43%,B组患者血清TC、TG、LDL-c、CRP、IL-6和TNF-α的水平较A组升高,脂联素水平下降,差异有统计学意义;而BM和HDL-c两组间差异无统计学意义。结论冠心病患者有较高的代谢综合征发病率,血脂代谢异常和炎性反应,明显提高代谢综合征患者发生冠心病的风险。

Objective To analysis of metabolic syndrome in patients with coronary heart disease of lipid metabolism and inflammatory factors, on lipid metabolism and inflammatory factor in coronary heart disease treatment early diagnosis significance. Methods A retrospective analysis of 2010 January to 2011 June in our hospital treatment for patients with coronary artery disease in 168 cases, divided into group A and group B, group A for patients with coronary heart disease does not reach the diagnostic criteria of metabolic syndrome cases, group B was consistent with the diagnostic criteria of metabolic syndrome cases, detection of serum CRP, IL-6, TNF - A, TC, TG, LDL-c, HDL-c and adiponectin concentration of indicator. Results The metabolic syndrome in patients with coronary heart disease incidence rate was 46.43% in B group, serttm TC, TG, LDL-c, CRP, IL-6 and TNF-a level than that of A group increased, decreased adiponectin levels, the difference was statistically significant; and BM and HDL-c two showed no significant difference between groups. Gonclusion Patients with coronary artery disease have a higher incidence of metabolic syndrome, abnormal lipid metabolism and inflammatory reaction, improve metabolic syndrome occurring in patients with coronary heart disease risk.