L-谷氨酸-5-甲酯金属铜化合物的合成、表征及生物活性

Synthesis,Characterization and Biological Activity of Metal Copper Complex with 5-Methyl-L-Glutamate

通过L-谷氨酸-5-甲酯与Cu(CH3COO)2.H2O反应,合成了相应的金属铜化合物[Cu(C6H10NO4)2].对L-谷氨酸-5-甲酯金属铜化合物的晶体进行了X-射线单晶衍射测定.结果表明:L-谷氨酸-5-甲酯金属铜化合物属单斜晶系,P2(1)空间群,其中a=9.5883(19),b=5.1521(10),c=15.562(3);β=98.65(3)°.抗菌筛选数据表明,L-谷氨酸-5-甲酯金属铜化合物对枯草芽胞杆菌具有较好的抑制作用.

A novel copper complex [ Cu（ C6H10NO4 ）2]~ was synthesized via the reaction of 5-methyl-L-glutamate with Cu （CH3 COO）2· H2O in water solution and its structure of [ Cu （C6H10 NO4 ）2] was determined by X-ray diffraction. The results indicated that it crystallizes in the monoclinic system and spaces in group P2 （ 1 ） with a = 9. 5883 （19） A^°, b = 5. 1521 （10）A^°, c = 15. 562 （3）A^°; β = 98.65 （3）A^°. Moreover, [ Cu（ C6H10NO4 ）2 ] has strong antimicrobial activity against Bacillus subtilis.