不同民族大学生乙肝病毒基因型分布状况调查

Study on the Distribution of HBV Genotype among Undergraduates from Different Nationalities

为了解不同民族大学生乙型肝炎病毒(hepatitis B virus,HBV)基因型和亚型分布状况,采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)技术,对中南民族大学93例来自15个民族乙肝大三阳学生血清HBV进行基因分型.结果表明:患者中HBV基因B型占61.3%(57/93),C型占25.8%(24/93),D型占4.3%(4/93).说明各民族HBV基因型分布中,B型占绝对优势,C型次之,D型最少(P<0.01).且不同民族不影响HBV基因型的分布(P>0.05),C型和D型分布基本符合我国HBV基因型地理区域分布规律.

To investigate the distribution of Hepatitis B virus genotype and subgenotype among undergraduates from various nationalities, 93 HBV-DNA positive serum samples from 15 nationalities in South-Central University for Nationalities were analyzed by PCR-RFLP. The results indicated that HBV genotype B accounted for 61.3% （57/93）, genotype C accounted for 25.8% （24/93） and genotype D accounted for 4.3% （4/93）. This demonstrated that genotype B is dominant in all the nationalities, genotype C ranks secondly and least genotype D （ P 〈 0. O1 ）. Ethnic differences have no effect on the classification of HBV genotype （ P 〉 0. 05 ）. Moreover, distribution of genotype C and D basically coincides with the geographic distribution of HBV in China.