治疗急性缺血性脑中风神经保护药物研发的进展和展望

Research and Development of Neuroprotective Drugs for Acute Ischemic Stroke Therapy: Past and Future

指出了在过去的几十年的时间内,超过1000多种在细胞和动物模型研究上被认为是有效的化合物或制剂在应用到人体的临床实验时导致失败.从脑中风的发病机制、神经保护药物研发的主要思路和存在的问题作了回顾性的分析和综述,并指出了将来治疗急性缺血性脑中风新药研发的趋势和新的研究策略和方法.

All attempts at treating strokes by pharmacologically reducing the human braing vulnerability to ischemia have failed, this is why stroke is still a leading cause of death, disability and massive socioeconomic loss worldwide. Over decades, research has failed to translate over 1,000 experimental treatments or new compounds from discovery in cells and animal models to use in humans. In this paper, we have reviewed several issues related to the mechanisms, key ideas for research and development of neuroprotective drugs and the problems. In addition, the research trends and new strategies and methods for the development of new drugs for acute ischemic stroke therapy have pointed out.