血小板抗体检测及配型对血小板输注无效的临床意义

The clinical significance of platelet antibody detection and platelet cross-matched on platelet transfusion refractoriness

目的通过对比血小板配型前后血小板的输注效果,评估血小板抗体检测及配型对血小板输注无效的临床意义。方法以出血症状改善情况、血小板计数增高指数(CCI)、血小板恢复百分率(PPR)为标准,对比配型前后血小板的输注效果。结果 25例血小板输注无效患者的血小板抗体筛查阳性9例;9例血小板抗体阳性患者血小板交叉配型前后血小板输注有效率差异有统计学意义(P<0.01),配型后输注的1h和24hCCI、PPR数值明显高于配型前输注的。结论血小板抗体检测及血小板配型输注可以为患者选择适用的血小板,提高单采血小板的输注有效率,避免滥用血小板。

Objective To evaluate the clinical significance of platelet antibody detection and platelets cross-matched on platelet transfusion refractoriness by comparing the efficiency of transfusion before and after platelets cross-matched.Methods Regarding the improvement of haemorrhage symptom,corrected count increment（CCI）,percent platelet recovery（PPR） as the standard,the efficiency of transfusion of before and after platelets cross-matched were compared.Results In 25 cases of patients with platelet transfusion refractoriness,9 cases′ platelet antibody detection were positive.Transfusion efficiency rates of 9 cases were significantly different before and after platelets cross-matched（P〈0.01）.The values of CCI and PPR in 1 h and 24 h after transfusion were higher than before.Conclusion Platelet antibody detection and platelet cross-matched can improve the efficiency of single-donor platelet transfusion,and also avoid misusing platelet.