慢性乙型肝炎患者化学发光法数据的变化规律分析

Change law of chemiluminescence data in patients with chronic hepatitis

目的为了解慢性乙肝患者表面抗原消失前体内乙肝标志物定量数据的变化规律。方法通过两对半的化学发光法测定结果,利用统计学标准,处理几种常见慢性乙肝类型的数据结构,寻找乙肝标志物的变化规律。结果从数据中了解到乙肝标志物变化过程中,HBeAg、抗-HBe、抗-HBc的重要性,三种常见类型之间有明显的统计学差异(P<0.01);定量结果可见HBeAg均值下降和抗-HBe均值升高;HbsAg、HBsAb在不同类型中变化不大,没有统计学差异(P>0.05),能否判断慢性乙肝的变化规律有待探讨。结论两对半的定量检测,可以间接反映体内乙型肝炎病毒(HBV)复制活跃程度,掌握病情是否进入好转的变化规律,对药物疗效评价具有重要意义。

Objective In order to understand patients with chronic hepatitis b surface antigen before it disappeared body hepatitis b markers quantitative data rule of variation.Methods Through two half-and-half chemiluminescence method,using statistical standard measuring results,handle several common chronic hepatitis b type of data structure,looking for the change rule of hepatitis b markers.Results From the data in understanding arrives second liver markers change process,HBeAg,fight-HBe,fight-HBc the importance of three common types,there is a notable difference between,P0.01;Quantitative results visible HBeAg mean decrease and anti-HBe mean elevatory;HbsAg,HBsAb on different kinds of big changes,P〉0.05,not statistically significant,can judge the change rule of chronic hepatitis b needs to be discussed.Conclusion Two half-and-half quantitative detection can indirectly reflect the body HBV replication active degree.In hepatitis b treatment process,grasping the change rule of hepatitis b for is great significance for efficacy evaluation.