电气石驻极合成纤维对大鼠胶原性关节炎的保护作用

Protective effect of synthetic fibers with tourmaline on collagen - induced arthritis in rats

目的研究电气石驻极合成纤维对大鼠胶原性关节炎的保护作用。方法将Wistar大鼠分为对照组(5只)、模型组(12只)和保护组(13只);对照组常规饲养,模型组和保护组采用Ⅱ型胶原蛋白诱导建立大鼠关节炎模型,分别用普通合成纤维织物或电气石驻极合成纤维织物进行局部保护。观察大鼠足部的外观变化、利用排水法对大鼠足部体积进行测定,并对大鼠足部进行组织病理学切片观察。结果模型组大鼠关节肿胀较保护组严重,甚至出现关节变形强直;病理切片结果显示模型组大鼠左、右后足病变严重,保护组大鼠左、右后足关节病变均较模型组轻;从第2周开始,保护组各时间点左后足平均体积均小于模型组,其中第2、6、8、10和12周时的差异有统计学意义(P<0.05);保护组大鼠关节炎的发病率低于模型组。结论电气石驻极合成纤维织物对Ⅱ型胶原蛋白诱导大鼠关节炎的发生具有保护作用。

Objective To investigate the protective effect of synthetic fibers with tourmaline on collagen-induced arthritis in rats.Methods Wistar rats were randomly divided into three groups,namely,the control（n = 5）,model（n = 12）,and protected（n = 13） groups.Rheumatoid arthritis（RA） was induced by immunization with typeⅡcollagen in Freund’s incomplete adjuvant in model group and protected group.Animals in model group were protected by conventional synthetic fibers and those in protected group were protected by the synthetic fibers with tourmaline.The protective effects were evaluated by comparing the appearance,volume（water drainage method）,and pathological changes of rat paws in different groups.Results Rats in model group exhibited more severe arthrocele than those in the protected group,and there was even arthrentasis.Histological analysis showed that the model group had more severe pathological changes in both left and right hindpaws than the protected group.Since the second week,the mean volumes of left hindpaws of protected group were smaller than those of model group,with the differences at week 2,6,8,10,and 12 being significantly different（P〈0.05）.The protected group also had a lower incidence of RA than the model group.Conclusion Synthetic fibers with tourmaline have protective effect against collagen Ⅱ-induced arthritis in rats.