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治疗炎性疾病的新靶点——α7烟碱型乙酰胆碱受体 被引量：6

Alpha7 nicotinic acetylcholine receptor:a novel therapeutic target for inflammatory diseases
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摘要 胆碱能抗炎通路是新近发现的一种神经-免疫调节通路,其潜在的药物作用靶点是α7烟碱型乙酰胆碱受体(α7 nicotinic acetylcholine receptor,α7nAChR)。近年来大量的研究证明特异性激动α7nAChR能够有效减少促炎细胞因子的释放。本文综述了α7nAChR在炎性疾病发生发展中的作用,拟为炎性疾病的治疗提供新的理论和思路。 The cholinergic anti-inflammatory pathway（CAP） is a new neurophysiologic mechanism regulating the immune system,with alpha7 nicotinic acetylcholine receptor（α7nAChR） being its potential pharmacological target.Cumulative studies have demonstrated that activation of α7nAChR can inhibit inflammation through modulating pro-inflammatory cytokines.The role of α7nAChR has been confirmed in a series of inflammatory diseases.This review is aimed to provide new insights for using α7nAChR against inflammatory diseases.
作者 陈基快 倪敏 沈甫明
机构地区 第二军医大学药学院药理学教研室 第二军医大学长征医院药剂科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2012年第8期897-899,共3页 Academic Journal of Second Military Medical University
关键词 胆碱能抗炎通路 Α7烟碱型乙酰胆碱受体 炎性疾病 cholinergic anti-inflammatory pathway alpha 7 nicotinic acetylcholine receptor inflammatory diseases
分类号 R364.5 [医药卫生—病理学]
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参考文献25

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同被引文献47

  • 1付燕,胡本容,汤强,付琴,张庆业,向继洲.药根碱、小檗碱、黄连煎剂及模拟方对小鼠血糖的影响[J].中草药,2005,36(4):548-551. 被引量：57
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引证文献6

二级引证文献18

第二军医大学学报
2012年 第8期

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