颈动脉粥样硬化斑块及超敏-C反应蛋白与短暂性脑缺血发作的关系

Relationship of Carotid Atherosclerotic Plaque and High-sensitivity C-reactive Protein to Transient Ischemic Attack

目的探讨颈动脉粥样硬化斑块、超敏-C反应蛋白(high sensitivity C-reactive protein,hs-CRP)与短暂性脑缺血发作(transient ischemic attack,TIA)的关系。方法对91例TIA患者(病例组)和90例对照者行颈动脉超声,观察颈动脉斑块性质,并行血清hs-CRP浓度检测。结果与对照组相比,病例组斑块发生率(54例,59.34%)及软斑块发生率(21例,23.08%)均明显升高,hs-CRP与颈动脉粥样硬化斑块性质有显著相关,P<0.05。结论颈动脉粥样硬化斑块、hs-CRP与短暂性脑缺血发作密切相关。

Objective To investigate the relationship of carotid atherosclerotic plaque（CAP） and high-sensitivity C-reactive protein（hs-CRP） to transient ischemic attack（TIA）.Method Characteristics of CAP were determined by carotid ultrasonography and hs-CRP levels were mearsured in 91 TIA patients and 90 healthy controls.Results Compared with controls,TIA significantly increased the incidence of CAP（59.34%,54 patients） and incidence of soft plaque（23.08%,21 patients）.The levels of hs-CRP were significantly correlated with characteristics of CAP（P〈0.05）.Conclusion Both CAP and hs-CRP were correlated with TIA.