急性颅脑损伤患者血浆D-二聚体含量分析

Plasma D-dimer Levels in Patients with Acute Craniocerebral Injury

目的探讨急性颅脑损伤患者病变血浆D-二聚体含量变化,分析其在发病中的临床意义。方法静脉采血,血凝仪检测急性颅脑损伤患者病变过程中的血浆D-二聚体含量。结果急性颅脑损伤患者疾病发展中血浆D-二聚体含量均增高,其在入院前、入院后5d、入院后7d血浆D-二聚体含量分别为(0.40±0.09)、(2.20±0.38)、(3.50±0.72)mg.L-1,高于健康体检者。结论通过检测血浆D-二聚体含量,对早期干预治疗,病情判断及预后,以及防止不可逆性脑缺血病变具有重要意义。

Objective To investigate the change in plasma D-dimer levels in patients with acute craniocerebral injury and its clinical significance.Methods Venous blood samples were taken from patients with acute craniocerebral injury to detect plasma D-dimer levels during disease development.Results The increase in plasma D-dimer levels was associated with disease development.The levels of plasma D-dimer were（0.40±0.09） mg/L,（2.20±0.38） mg/L and（3.50±0.72）mg·L-1 before admission,at 5 days after admission and at 7 days after admission,respectively.Compared with healthy subjects,plasma D-dimer levels significantly increased in patients with acute craniocerebral injury.Conclusion The measurement of plasma D-dimer is important to early intervention,prognostic evaluation and prevention of irreversible brain ischemic lesions.