普罗帕酮预防肺切除术后房颤的临床研究

Propafenone in the Prevention of Atrial Fibrillation After Pulmonary Resections

目的:探讨口服普罗帕酮预防肺切除术后发生房颤的效果。方法:将499例肺切除术患者按有无肺切除术后房颤的高危因素(年龄≥60岁、≥2个肺叶切除)以及是否口服普罗帕酮预防分为给予普罗帕酮干预的高危研究组(n=139)、未予普罗帕酮干预的高危对照组(n=223)和低危研究组(n=137)。比较3组间房颤发生率的差异。结果:高危研究组房颤发生率显著低于高危对照组(5.15%比12.56%,P=0.047),而高危研究组和低危研究组的房颤发生率无显著差异(5.15%比2.22%,P=0.291)。结论:肺切除术后房颤高危患者预防性口服普罗帕酮可以降低其房颤的发生率。

Objective：To evaluate the effect of propafenone in the prevention of atrial fibrillation （AF） after pulmonary resec- tions. Methods： A total of 499 patients underwent pulmonary resections were enrolled. According to the risk for AF, they were divided into high risk group （n = 362） and low risk group （n = 137）. Among the patients in the high risk group, 139 were pretreated with propafenone orally （propafenone group）, and the other 223 patients constituted the control group. Results： There was a significant difference in the incidence of AF between and control group, however, there was no significant difference be- tween and low risk group. Conclusion： Propafenone can decrease incidence of AF after lung resections.