静脉药物配置中心24h运行模式下批量配置顺铂方法探讨

目的探讨静脉用药调配中心（PIVAS）批量配置顺铂的操作方法，以保证患者及时、准确用药。方法实验组和对照各200支顺铂。实验组将顺铂充人溶媒后放振荡器振荡1min后放人恒温水浴中，根据水温将实验组分为5个亚组，每亚组40支顺铂，即A组（水温46oC）、B组（水温48oC）、C组（水温50oC）、D组（水温52℃）、E组（水温54℃）。

Objective To explore the suitable way of batch cisplatin dissolution in pharmacy intravenous admixture service (PIVAS) and ensure the patients' receive medicine timely and accurately.Methods All samples were divided into control group and experiment group,with 200 cisplatinum in each group.The control group added dissolvent and then oscillated for 30 min,and the dissolve time of cisplatin was observed.The experiment group put the cisplantin into warm water after oscillation for 1 min.According to the water temperature,five subgroups were divided into five subgroups with each group 40 cisplantin:subgroup A (water temperature 46 ℃ ),subgroup B ( water temperature 48 ℃ ),subgroup C ( water temperature 50 ℃ ),subgroup D( water temperature 52 ℃ ) and subgroup E( water temperature 54 ℃ ).The state of cisplatin dissolve every one minute and dispensing time were recorded.Results Compared with the control group,the cisplatin in the experiment group was solved more completely,and the difference was statistically significant( x2 =9.087,P＜0.05).With the step-up of water temperature,the number of the dissolved cisplatin in 5 min of experimental subgroups gradually increased,subgroup A,9 cases (22.5％) ;subgroup B,28 cases (70％) ;subgroup C,34 cases (85％) ;subgroup D,40 cases ( 100％ ),and 33 cases in subgroup D,40 cases in subgroup E within 3 min.Conclusions In PIVAS 24-h continuous mode,the way of cisplatin dissolve by heat and oscillation for 1 min,with the water temperature keeps 52 ℃ and dissolve time in 5 min is a faster and effective method.This mode can save time and improve efficiency.