肾细胞癌免疫治疗的历史与研究进展
摘要
由于肾癌具有对放、化疗的高度不敏感性,使得免疫疗法在转移性肾癌患者的治疗中尤为重要。一些研究报告了在基于免疫治疗的基础上,诸多学者尝试利用抗原、细胞因子、树突细胞等不同方法进行大量的临床试验,安全性有目共睹,但长期的临床疗效无法在多数人群中体现。本文旨在对细胞介导的肿瘤免疫疗法作出整体描述,并探讨近年来有关肾细胞癌在临床试验中的免疫治疗进展。
出处
《国际泌尿系统杂志》
2012年第4期478-481,共4页
International Journal of Urology and Nephrology
参考文献37
-
1Jemal A, Siegel R, Ward E, et al. Cancer statistics. CA Cancer J Clin,2009, 59(4) :225 -249.
-
2Alexandrescu DT, Dasanu CA. Kidney cancer therapy: new per- spectives and avenues. Expert Opinion on Pharmacotherapy, 2006, 7(18) :2481 -2493.
-
3Yang JC, Childs R. Immunotherapy for renal cell cancer. Joumal of Clinical Oncology, 2006, 24 (35) :5576 - 5583.
-
4Motzer R J, Bukowski RM. Targeted therapy for metastatic renal cell carcinoma. Journal of Clinical Oncology, 2006, 24 ( 35 ) :5601 - 5608.
-
5Finke JH, Rayman P, Edinger M, et al. Characterization of a hu- man renal cell carcinoma specific cytotoxic CD8 T cell line. Journal of Immunotherapy, 1992, 11 ( 1 ) : 1 - 11.
-
6Brouwenstijn N, Gaugler B, Krase KM, et al. Renal cell carcino- ma - specific lysis by cytotoxic T - lymphocyte clones isolated from peripheral blood lymphocytes and tumorinfihrating lymphooytes. In- ternational Journal of Cancer, 1996, 68 (2) : 177 - 182.
-
7Gaudin C, Kremer F, Angevin E, et al. A hsp70 -2 mutation recognized by CTL on a human renal cell carcinoma. Journal of Im- munology, 1999, 162(3) :1730 - 1738.
-
8Childs R, Chemoff A, Contentin N, et al. Regression of metastat- ic renal cell carcinoma after nonmyeloablative allogeneic peripheral - blood stem - cell transplantation. New England Journal of Medi- cine, 2000, 343( 11 ) :750 -758.
-
9Rini BI, Zimmerman T, Stadler WM, et al. Allogeneic stem - cell transplantation of renal cell cancer after nonmyeloablative chemo- therapy: feasibility, engraftment, and clinical results. Joumal of Clinical Oncology, 2002, 20 (8) :2017 - 2024.
-
10Belardelli F, Ferrantini M, Proietti E, et al. Interferon -alpha in tumor immunity and immunothcrapy. Cytokinc and Growth Fac- tor Reviews, 2002, 13(2) :119 -134.
-
1杨旭,刘风玲.粉防己碱在逆转肿瘤化疗多药耐药性中的作用[J].现代中西医结合杂志,2011,20(15):1942-1944. 被引量:4
-
2张国楠.对晚期卵巢癌综合治疗模式的思考[J].肿瘤预防与治疗,2012,25(3):131-134. 被引量:3
-
3张友会.介绍一种治疗肿瘤肺转移的新途径[J].中国肿瘤生物治疗杂志,1997,4(3):174-175. 被引量:5
-
4李良久.肿瘤的免疫疗法进展[J].重庆医学,1994,23(4):252-253.
-
5周志强.细胞因子与肿瘤免疫治疗[J].肿瘤防治研究,1998,25(5):422-423.
-
6周丹,戴松林.白细胞介素Ⅱ、LAK细胞治疗中晚期恶性肿瘤28例[J].人民军医,1993,36(9):64-65.
-
7杜竞辉,王学浩,文跃进,王萱仪.应用LAK/IL_2治疗14例晚期肿瘤的临床研究[J].江苏医药,1994,20(8):435-437.
-
8刘振华,彭孝伟.瘤苗的研究近况[J].癌症,1996,15(4):307-308.
-
9SatoGH,SatoJD,刘世平.生长因子受体单克隆抗体和肿瘤免疫疗法[J].国外医学(肿瘤学分册),1990,17(3):158-159.
-
10Susan Mayor,吕小东(译).研究聚焦前列腺特异性抗原筛查的不敏感性[J].英国医学杂志中文版,2005,8(5):273-274.