脑梗死合并2型糖尿病的发生与颈动脉粥样硬化的相关性

Relationship between cerebral infarction combined with type 2 diabetes and carotid atherosclerosis

目的探讨脑梗死合并2型糖尿病与颈动脉粥样硬化之间的关系。方法选择自2010年1月至2011年12月合肥市第二人民医院收治的脑梗死合并2型糖尿病患者132例f观察组），与同期单纯2型糖尿病患者150例（对照组）进行生化指标的对比分析，其中全自动生化分析仪检测2组患者C反应蛋白、高同型半胱氨酸、三酰甘油等，胆固醇氧化酶法测总胆固醇、高密度脂蛋白、低密度脂蛋白，免疫比浊法测纤维蛋白原，彩色多普勒超声检查颈动脉粥样硬化斑块的形成情况。结果观察组C反应蛋白、高同型半胱氨酸和低密度脂蛋白水平明显高于对照组，差异有统计学意义（P〈0．05）。观察组高密度脂蛋白水平明显低于对照组，差异有统计学意义（P〈0．05）。观察组颈动脉粥样硬化不稳定型斑块检出率（54．5％）明显高于对照组（21．3％1，差异有统计学意义（P〈0．05）。结论颈动脉粥样硬化与脑梗死合并2型糖尿病的发生有密切关系。

Objective To investigate the relationship between cerebral infarction combined with type 2 diabetes and carotid atherosclerosis. Methods One hundred and thirty-three patients with diabetes complicated with cerebral infarction and 150 patients with type 2 diabetes （controls）, admitted to our hospital from January 2010 to December 2011, were chosen in our study. The levels of homocysteine （Hcy） and triglyceride （TG） were detected with automatic biochemical analyzer; cholesterol oxidase method was employed to measure the levels of total cholesterol （TC）, high-density lipoprotein （HDL） and low-density lipoprotein （LDL）; immunoturbidimetric assay was used to detect the level of fibrinogen （FIB） and the formation of artherosclerotic plaque. Results The levels of c-reactive protein, Hcy and LDL in the observation group were significantly higher than those in the control group （P〈0.05）. The HDL level in the observation group （1.11±0.28 mmol/L） was obviously lower than that in the control group （1.53±0.37 mmol/L, P〈0.05）. The detection rate ofartherosclerotic plaque in observation group （54.5%） was significantly higher than that in the control group （21.3%, P〈0.05）. Conclusion A close relationship between carotid atherosclerosis and cerebral infarction complicated with type 2 diabetes is noted.