摘要
目的评价血清高迁移率族蛋白-1(high mobility group box-1,HMGB-1)与急性冠状动脉综合征患者左室射血分数的关系。方法急性冠状动脉综合征患者121例(ACS组)及体检健康者42例(对照组),比较2组血清HMGB-1水平及左室射血分数、左心室舒张期末径、左心室收缩期末径及二尖瓣口血流E/A峰值比。结果 ACS组患者血清HMGB-1水平明显高于对照组(P<0.05);与对照组比较,ACS组左室射血分数及E/A明显降低,而左心室收缩期末径明显增大(P<0.05);血清HMGB-1水平与左室射血分数呈明显负相关(r=-0.299,P<0.01)。结论血清HMGB-1水平可反映急性冠状动脉综合征患者的左室射血分数,有助于评价其心脏收缩功能。
Objective To investigate the association of high mobility group box-1 （HMGB1） level with the left ventricular ejection fraction （LVEF） in patients with acute coronary syndrome （ACS）. Methods A total of 121 patients with ACS and 42 healthy controls were compared serum HMGB-1 level, LVEF, left ventricular end diastolic diameter （LVDD）, left ventricular end systolic diameter （LVDS） and mitral valve E/A. Results Serum HMGB-1 level was significantly higher in ACS group than that in control group （P〈0.01）. LVEF and mitral valve E/A were significantly lower, and LVDS was significantly longer in ACS group compared with control group （P〈0.05）. HMGB-1 level was significantly and negatively correlated with LVEF （P〈0.01）. Conclusion Serum HMGB-1 level can reflect the LVEF value, which helps to evaluate cardiac systolic function in patients with ACS.
出处
《中华实用诊断与治疗杂志》
2012年第8期753-754,共2页
Journal of Chinese Practical Diagnosis and Therapy
基金
福建省自然科学青年基金(2010J05064)
