慢性丙型肝炎发生肝脂肪变与脂联素的关系

Relationship between adiponectin and hepatic steatosis in patients with chronic hepatitis C

目的探讨慢性丙型肝炎(chronic hepatitis C,CHC)患者发生肝脂肪变与脂联素的关系。方法 80例CHC患者分为有肝脂肪变组8例与无肝脂肪变组72例,单纯非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)26例为对照组,比较各组血清脂联素等生化指标。结果 2组CHC患者糖代谢及脂代谢指标、丙型肝炎病毒核糖核酸水平、血清脂联素水平、肝脏炎症程度比较差异均无统计学意义(P>0.05),CHC组血清脂联素水平高于NAFLD组(P<0.01);脂联素与年龄、谷丙转氨酶、谷草转氨酶和丙型肝炎病毒核糖核酸水平呈正相关(P<0.05),与低密度脂蛋白胆固醇、载脂蛋白-B、三酰甘油和空腹血糖水平呈负相关(P<0.05)。结论 CHC患者发生肝脂肪变与血清脂联素无关;血清脂联素与年龄、肝脏炎症程度和丙型肝炎病毒核糖核酸水平呈正相关,与血糖、血脂水平呈负相关。

Objective To investigate the relationship between adiponectin and hepatic steatosis in Chinese adults with chronic hepatitis C （CHC）. Methods A total of 80 patients with untreated CHC were divided into hepatic steatosis group （n=8） and no-steatosis group （n=72）, and another 26 patients with non-alcoholic fatty liver disease （NAFLD） were as controls. The serum adiponectin levels were compared. Results There were no significant differences in plasma glucose level, lipid level, serum adiponectin level, hepatitis C virus RNA titer, or the degree of hepatitis between two groups of CHC （P〉0.05）. The serum adiponectin level in CHC patients was significantly higher than that in NAFLD patients. Serum adiponectin was significantly positively correlated with the age, glutamic-pyruvic transaminase, glutamie- oxaloacetic transaminase and hepatitis C virus RNA titer （P〈 0.01）, and negatively correlated with serum low density lipoprotein-cholesterol, apolipoprotein-B, serum triacylglycerol and fasting plasma glucose （P〈 0.05）. Conclusion Hepatic steatosis in CHC is not correlated with the level of serum adiponectin. Serum adiponectin level is positively correlated with the age, the degree of hepatitis and hepatitis C virus RNA level and negatively correlated with plasma glucose and lipid level.