阿托伐他汀对急性心肌梗死患者择期PCI术后心肌灌注及心功能的影响被引量：4

Effects of atorvastatin on improving myocardium reperfusion and heart function in patients with acute myocardial infarction after delayed percutaneous coronary intervention

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摘要目的:探讨阿托伐他汀对急性心肌梗死患者择期介入治疗(PCI)后心肌灌注及心功能的影响。方法:选择在我院行择期PCI治疗的急性心肌梗死患者120例,随机分为阿托伐他汀组60(例)和对照组(60例)。阿托伐他汀组于PCI术前1周开始给予阿托伐他汀20mg每晚一次,观察阿托伐他汀组与对照组PCI术后15min校正的TIMI帧数计数(CTFC),同时行冠状动脉血流速度测定。术后2周行心肌核素显像分析,计算心肌灌注显像积分,应用QG SPECT软件再次处理,得到左室射血分数(LVEF)、左室收缩末期容积(LVESV)及左室舒张末期容积(LVEDV)等心功能指标。结果:阿托伐他汀组校正的TIMI帧数计数明显低于对照组(26.28!5.71)vs(35.12!6.18);冠状动脉血流速度高于对照组(151.23!36.7)mm/s vs(130.82!40.2)mm/s;阿托伐他汀组术后2周心肌灌注显像积分低于对照组(2.0!0.5)vs(3.5!0.6);左室射血分数明显高于对照组(0.58±0.05)vs(0.41±0.08);左室收缩末期容积、左室舒张末期容积低于对照组(56.6±1.4)mm vs(63.1±0.8)mm,(44.7±1.4)mm vs(52.8±2.5)mm,差异均有统计学意义。结论:急性心肌梗死患者择期PCI术前给予阿托伐他汀治疗可改善心肌灌注及心功能。 Objective： To explore the effects of atorvastatin on myocardium reperfusion and heart function in patients with acute myocardial infarction after delayed percutaneous coronary intervention（PCI）.Methods： 120 patients with acute myocardial infarction（AMI） were randomly divided into 2 groups,atorvastatin-treated group（60 cases） and routine-treated group（60 cases）.The patients in the two groups were all received the coronary secondary prevention,the atorvastatin-treated group added atorvastatin（20mg,one time per day） on 7 days beforePCI.The corrected TIMI frame count（CTFC）,coronary blood welocity were observed on 15minutes after PCI.Analysis of myocardial perfusion tomography in two patients was performed on 2 weeks after PCI.The indices of cardiac function in two groups including LVEF,LVEDD and LVESD were measured by QG SPECT soft.Results： The corrected TIMI frame count（CTFC）in atorvastatin-treated group were significantly lower than those in control group（26.28±5.71）vs（35.12±6.18）,but coronary blood welocity in atorvastatin-treated group were significantly higher than those in control group（151.23±36.7）mm/s vs（130.82±40.2）mm/s.In atorvastatin-treated group,points of myocardial perfusion imaging（2.0±0.5）were significantly lower than those in routine-treated group（3.5±0.6）.In atorvastatin-treated group,left ventricular end diastolic volume（56.6±1.4）and left ventricular end systolic volume（44.7±1.4）were all decreased while left ventricular ejection fraction（0.58±0.05）improved markedly than those in controls（0.41±0.08）.Conclusion： Administration of atorvastatin before delayed PCI may significantly improve myocardial microvascular perfusion and cardiac function.

作者李勇郑群杨红梅张颖轩张慧晶张俊岭李拥军

机构地区河北省衡水市哈励逊国际和平医院河北医科大学第二医院心内科

出处《陕西医学杂志》 CAS 2012年第7期816-818,共3页 Shaanxi Medical Journal

关键词心肌梗塞/药物疗法@阿托代他汀放射摄影术介入性心肌灌注显像 Myocardial infarction/drug therapy @Atorvastatin Radiography interventional Myocardial perfusion imaging

分类号 R541.4 [医药卫生—心血管疾病]

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参考文献11

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