全身型儿童类风湿关节炎21例预后因素分析

The prognosises factor analysis of 21 cases of whole body type of juvenile rheumatoid disease

目的:探讨全身型儿童类风湿关节炎临床特点与预后因素,以提高对全身型儿童类风湿关节炎的认识。方法:对21例全身型儿童类风湿关节炎患儿进行统计,并分析相关资料。结果:甲氨蝶呤的治疗对全身型儿童类风湿关节炎完全缓解有重要意义;多关节炎者和类风湿因子,C反应蛋白,血小板的增高,不利于疾病的缓解;年龄小的患儿和女性患儿远期致残率较高。结论:全身型儿童类风湿关节炎的预后差,有较高的致死致残率,在病情反复发作>5年的患儿,均发生了破坏性的关节病变。应及早诊断,及早治疗,包括甲氨蝶呤在内的联合方案,缩短肾上腺糖皮质激素的疗程和减少其剂量,监测各种感染的发生,以改善其预后。

Objective： To study the the clinical characteristics and the Prognostic factors of the whole body type of juvenile rheumatoid disease and to improve the cognition to the whole body type of juvenile rheumatoid disease. Methods： summarize and analyze the relevance data of 21 cases of whole body type of juvenile rheuma- toid disease received. Results：Methotrexate can compeletely ease rheumatoid festival body children inflammation, which has important significance; Multi-arthritis and rheumatoid factor, c-reactive protein, and platelet heighten are detrimental to the alleviation of the disease; Small children and women has higher long-term disability oc- currence . Conclusion： the whole body type of juvenile rheumatoid disease arthritis prognosis is poor, with high mortality morbidity, repeated breaking out 〉 5 years among children with destructive joint lesions.Early diagnosis and early treatment are important. Combined program including methotrexate can shorten the adrenal cortical hor- mone treatments, reduce agent quantity, monitor various infection, and improve the prognosis.