白念珠菌生物被膜的基因表达及相关基因研究进展

Biofilm gene expression and biofilm-related genes of Candida albicans:an update

白念珠菌是一种条件性致病菌,可在人体植入性器械表面形成生物被膜。与浮游和以个体形式存在的白念珠菌相比,生物被膜在结构及功能上有很大差异,这种差异本质上是由基因表达决定的。近年来,研究者们试图通过芯片和基因敲除等技术手段,探索与白念珠菌生物被膜形成及耐药相关的基因,揭示其分子机制,寻找药物作用的新靶点。

Candida albicans is an opportunistic fungal pathogen with the ability to form biofilms on in-planted medical devices. Cells in biofilms display a phenotype that is markedly different from their planktonic and free-living counterparts in both form and function. Recent advances in microarray and genetic manipulation have begun to clarify the mechanisms that govern C. albicans biofilm development and acquisition of such unique phenotype, These studies are considered to be important in finding new targets of antifungal drugs.