孕酮、β-HCG、PAPP-A联合检测对妊娠结局的诊断价值

目的:探讨早期妊娠妇女血液中孕酮、β-HCG、妊娠相关血浆蛋白A(PAPP-A)联合检测对妊娠结局的诊断价值。方法:收治5～12周早期妊娠妇女699例,根据妊娠结局(所有患者均通过随访确诊)分为5组,正常妊娠组385例、先兆流产组98例、稽留流产组53例、异位妊娠组76例、胎儿宫内发育不良组87例。监测各组血清孕酮、β-HCG、妊娠相关血浆蛋白A(PAPP-A)。结果:血清孕酮、PAPP-A、β-HCG动态检测结果在稽留流产、异位妊娠、胎儿宫内发育不良组与先兆流产组间,在先兆流产组与正常妊娠组间比较明显降低,差异有统计学意义(P<0.05)。结论:在妊娠早期,血清孕酮、PAPP-A和β-HCG联合检测对妊娠结局有较大的诊断价值。

Objective：To study it＇s diagnosis value for pregnancy outcome, combined detection of serum progesterone, β - HCG and pregnancyassociated plasma protein A （PAPP - A ） in early pregnant women was carried out. Methods：The blood samples of 699 women that gestation age of 5 - 12 weeks from our outpatients and inpatients （May 2010 to October 2011 ）were collected to do progesterone, β - HCG and pregnancy - associated plasma protein A （ PAPP - A ） detection. On the basis of result of pregnancy the patients were divided into five groups： normal pregnancy （ 385cases ）, threatened abortion（98cases） , missed abortion （ 53cases ） , ectopic pregnancy （ 76 cases） and poor intrauterine fetal growth（87cases）. Results： The blood progesterone, pregnancy - associated plasma protein A（ PAPP - A） and β - HCG levels showed statistically significant difference （ P 〈 0.05 ） between threatened abortion group and other abnormal groups （ missed abortion, ectopic pregnancy and poor intrauterine fetal growth） ,the same difference was found between threatened abortion and normal preg- nancy. All group samples were in a low level compared to the normal ones. Conclusion： During the early pregnant period, combined detection of serum progesterone, β - HICG and PAPP - A can be considered as an early diagnostic method to forecast the pregnancy outcome.