摘要
转录后基因调控异常与阿尔茨海默病(Alzheimer's disease,AD)发生发展的关系研究越来越受到重视.本文重点论述了tau基因(MAPT)发生可变剪接异常与AD发生的关系,以及参与转录后调控的RNA结合蛋白和非编码RNA在AD发生发展中的作用.
Post-transcriptional regulation plays a central role in the development and maintenance of the nervous system. Defects in post-transcriptional regulation lead to neurodegenerative diseases. Mounting evidence suggests that the impaired post-transcriptional regulation of associated genes contribute to the neurodegenerative process, such as Alzheimer＇s disease （AD）. This review discusses the role of disruption of alternative splicing regulation of the human tau gene （MAPT） and alterations of microRNA expression in the pathogenesis of neurodegeneration including AD. A brief overview is provided for the role and the mechanism of post-transcriptional regulation in AD pathogenesis.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2012年第8期703-708,共6页
Progress In Biochemistry and Biophysics
基金
国家重点基础研究发展计划(973)(2009CB825400,2010CB529600)
国家自然科学基金(91132710)资助项目~~
