脑内线粒体雌激素受体β在女性阿尔茨海默病发生过程中的作用

The Role of Brain Mitochondrial Estrogen Receptor β in The Pathogensis of Female Alzheimer′s Disease

脑内雌激素水平下降被认为与女性阿尔茨海默病(AD)相关,女性阿尔茨海默病患者脑中胞浆、细胞核、线粒体中的雌激素受体β(estrogen receptorβ,ERβ)水平也较正常老年女性低.老年大鼠脑内ERβ水平发生显著下降.敲除ERβ影响小鼠的学习和记忆功能,雌激素或ERβ选择性激动剂能够改善神经元突触相关蛋白表达.在神经元中,ERβ与线粒体共定位,提示定位于线粒体上的ERβ,可能参与线粒体功能的调节,从而影响神经元功能.

The decrease of brain estrogen was considered to be closely involved in Alzheimer＇s disease in women. Moreover, less estrogen receptor β （ERβ） was detected in mitochondrial, nuclear, and cytosolic fractions of female AD brains. The level of brain ERβ in aged rats is also decreased significantly. ERβ depletion impairs learning and memory of mice, while estrogen or ERβ selective agonist could activate the expression of synapse related proteins. ERβ colocalizes with mitochondria in primary neuron, suggesting that ERβ might play roles in regulating mitochondrial function and affect the fimction of neuron accordingly.