血清YKL-40与2型糖尿病的相关性被引量：2

Correlation of serum YKL-40 with type 2 diabetes

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摘要目的探讨血清人软骨糖蛋白-39(YKL-40)的水平与2型糖尿病(T2DM)及肥胖的关系。方法按体重指数(BMI)将42例初诊T2DM患者分为肥胖组(A组,20例,BMI≥25)和非肥胖组(B组,22例,BMI<25)。非糖尿病正常对照者46例亦分为肥胖组(C组,22例,BMI≥25)和非肥胖组(D组,24例,BMI<25)。ELISA法测定四组血清YKL-40浓度。结果 A组和B组血清YKL-40浓度高于C组和D组[(81.25±12.82)ng/ml和(79.82±13.47)ng/ml vs.(44.84±6.51)ng/ml和(40.98±8.74)ng/ml](P<0.01)。A、B组或C、D组之间血清YKL-40浓度比较差异均无统计学意义(P>0.05)。相关分析显示,血清YKL-40水平与空腹血糖、糖化血红蛋白呈正相关(P<0.01)。多元线性逐步回归分析表明,空腹血糖、糖化血红蛋白是血清YKL-40水平的独立影响因素。结论YKL-40与T2DM密切相关,可能参与了T2DM的发生、发展。 Objective To evaluate the correlation of serum YKL-40 with type 2 diabetes mellitus（T2DM）and obesity. Methods On the basis of body mass index（BMI）, 42 newly diagnosed T2DM patients were divided into obese group（group A,20 cases,BMI≥25） and lean group（group B, 22 cases,BMI〈25）. Another 46 subjects without T2DM were divided into obese group（group C, 22 cases,BMI≥25） and lean group（group D, 24 cases, BMI〈25）. Serum concentration of YKL-40 was determined by ELISA. Results Serum levels of YKL-40 were higher in groups of A and B than those in groups of C and D [（81.25±12. 82） ng/ml and （79.82±13.47） ng/ml vs. （44. 84±6.51） ng/ml and （40. 98±8. 74） ng/ml] （P〈0. 01）, which were not significantly different between groups of A and B or between groups of C and D（P〉0. 05）. Correlation analysis showed that serum YKL-40 was positively correlated with fasting plasma glucose and HbAlc （P〈0. 01 ）. Stepwise linear multiple regression analysis showed that fasting plasma glucose and HbAlc were the independent determinants of YKL-40. Conclusion YKL-40 may play a role in the pathogenesis of T2DM.

作者钮利娟成兴波蒋志华韩俊霞徐文超张磊

机构地区苏州大学附属第一医院内分泌病科

出处《江苏医药》 CAS CSCD 北大核心 2012年第15期1803-1805,共3页 Jiangsu Medical Journal

关键词人软骨糖蛋白-39 2型糖尿病肥胖 Human cartilage glycoprotein-39（YKL-40） Type 2 diabetes mellitus Obesity

分类号 R587 [医药卫生—内分泌]

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