子宫内膜中的成体干细胞

Adult stem cells in the endometrium

背景:近年来子宫干细胞尤其是子宫内膜干细胞研究有了新的突破,多个学者用不同方式证明了子宫内膜干细胞的存在。目的:介绍子宫干细胞存在的依据、位置及表面标志物。方法:应用计算机检索1995-01/2010-12清华同方数据库相关文章,检索词为"子宫内膜干细胞",并限定文章语言种类为中文。同时计算机检索PudMed数据库相关文章,检索词为"endometrium stemcell",并限定文章语言种类为English。共检索到文献233篇,最终纳入符合标准的文献30篇。结果与结论:近年来子宫内膜干细胞的分离与鉴定研究有了很大的进展,但子宫内膜干细胞的特异性标志物仍在探索中。文章就克隆形成能力、标记滞留细胞实验及组织重建能力等多种方法对子宫内膜干细胞存在的可能性,存在部位以及可能的表面标志物等进行了综述。

BACKGROUND： In recent years, the studies on uterine endometrial stem cells, especially endometrial stem cells, have made great progress, many scholars have indentified the existence of endometrial stem cells through different ways. OBJECTIVE： To review the basis for the existence, location and surface markers of endometrial stem cells METHODS： Wanfang database was used to retrieve the articles published from January 1995 to December 2010 with the key words of ＂endometrium stem cell＂ in Chinese. The PudMed database was also used to search the articles published from January 1995 to December 2010 with the key words of ＂endometrium stem cell＂ in English. A total of 233 articles were retrieved. Finally, 30 articles were selected according to the inclusion criteria. RESULTS AND CONCLUSION： In recent years, the study on the isolation and identification of endometrial stem cells has made great progress, but the specific markers of endometrial stem cells were still need to be explored. Here, we will review our current understanding of the possibility existence, the possible location and the possible surface markers of endometrial stem cells through colony-forming ability, cell mark retention experiments and tissue reconstruction capacity