门控心肌灌注显像不同采集模式对左心室运动功能参数测定的影响

Influence of Gated Myocardial Perfusion Imaging with Different Acquisition Models on the Assessment of Left Ventricular Function

探讨每个心动周期8帧和16帧采集模式对门控心肌灌注显像(G-MPI)测定左心室运动功能参数的影响。前瞻性纳入2010年1月-2011年1月于四川大学华西医院核医学科拟行腺苷负荷/静息G-MPI的患者,利用共行成像技术,1次显像同时行16帧和8帧门控采集模式,采用Auto Quant软件分别计算两种采集模式所得的左心室舒张末期容积、收缩末期容积和射血分数(EF)。共48例患者的负荷/静息G-MPI纳入分析,其中男性29例,女性19例,平均年龄(51±16)岁。Bland-Altman一致性检验显示,负荷和静息状态下,16帧和8帧采集所得的EF值间的平均差值分别为3.13%(95%CI:5.93%～0.32%)和3.27%(95%CI:6.42%～0.12%)。16帧和8帧采集模式所获得的心肌缺血和(或)梗死患者的心室腔容积均较心肌灌注正常者大,相比EF值较心肌灌注正常者小。8帧和16帧采集模式不可相互替代来探测左心室EF。

This paper is aimed to investigate the influence of gated myocardial perfusion imaging （G-MPI） with 8- and 16-frame acquisition models on the assessment of left ventricular function. Patients prepared for stress and rest G- MPI were prospectively recruited from January 2010 to January 2011 in the Department of Nuclear Medicine of West China Hospital, Sichuan University. Two separate G-MPI studies, one with 8 and the other with 16 frames, were simultaneously acquired during a single gantry orbit using Concurrent Imaging technique. We calculated the left ven- tricular ejection fraction （EF） and volumes using the Auto Quant software. Forty-eight patients （29 men, 19 women; average age 51±16 years old） were finally analyzed. The differences in left ventricular EF between 8- and 16- frame were small：3.27%（95% CI： 6. 41%-0. 12%）for post-stress and 3.13%（95% CI：5.93%-0. 32%）for rest. Both using 8 and 16 frames, there were significantly larger volumes and lower EF in patients with stress-induced is- chemia than without. As for detecting left ventrieular EF, 8-frame and 16-frame acquisition models should not be mutually alternated.