摘要
RNAi是由小双链RNAs触发的序列特异性转录后基因沉默,RNAi具有锁定任何引起疾病或疾病相关蛋白表达的能力,有巨大的治疗应用前景。但以治疗为目的的siRNA特异、有效的递送仍是RNAi广泛治疗应用的主要障碍。本文就目前siRNA体内递送取得的研究进展进行综述,以有助于RNAi技术安全、有效的临床应用。
RNA interference （RNAi） is a powerful endogenous process initiated by short double stranded RNAs, which results in sequence-specific posttranscriptional gene silencing. Because any protein that causes or contributes to a disease is susceptible to RNAi, the RNAi has high potential for therapeutic treatments. In a clinical setting, how- ever, there are many obstacles to targeted delivery of small interfering RNA （siRNA） in vivo, specificity and stabili- ty of the RNAi reagents. In this review, we focus on recent progress in the development of efficient siRNA delivery vehicles to help the application of siRNA to in vivo therapy.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2012年第4期775-779,共5页
Journal of Biomedical Engineering
基金
国家自然科学基金资助项目(81060180)
甘肃省中青年基金资助项目(1107RJYA033)
关键词
RNA干扰
小干扰RNA
siRNA递送
靶向递送
RNA interference （RNAi）
Small interfering RNA（siRNA）
siRNA delivery
Targeted delivery
