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微管相关蛋白Tau磷酸化及其靶向抑制作用研究进展 被引量：3

Research Progress of Abnormal Phosphorylation of Microtubule-associated Tau Protein and of the Targeted Inhibition of the Phosphorylation
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摘要 进行性遗忘是阿尔茨海默病(AD)的主要临床表现,微管相关蛋白Tau(MAPT)高度磷酸化在AD和其它神经退变性疾病中扮演着关键性角色。本文拟从参与Tau蛋白磷酸化的激酶和磷酸酶以及基于靶向Tau激酶抑制和磷酸酶激活的治疗策略方面展开综述。 Progressive dementia is described as the first and most prominent symptom of Alzheimer＇s disease（AD）, and hyperphosphorylation of microtubule associated Tau protein （MAPT） p!ays a key role in neurodegeneration and neuronal dysfunction in AD and other neurodegenerative diseases. This paper reviews several protein kinases and phosphatases which can phosphorylate/dephosphorylate Tau protein, and evaluates a therapeutic strategy based on targeted inhibition of Tau kinases and activation of Tau phosphatases.
作者 周付涛 陈双容 陈双容(综述) 孙学川(审校)
机构地区 南昌航空大学体育学院 解放军军事体育进修学院
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2012年第4期788-792,共5页 Journal of Biomedical Engineering
关键词 TAU蛋白 Tau蛋白激酶 Tau蛋白磷酸酶 靶向抑制 Tau protein Tau kinases Tau phosphatases Targeted inhibition
分类号 R749.16 [医药卫生—神经病学与精神病学]
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参考文献26

  • 1LIU F, LIANG Z, SHI J, et al. PKA modulates GSK-3beta- and cdk5-catalyzed phosphoryIation of tau in site- and kinase- specific manners[J].FEBS Lett, 2006, 580(26) : 6259-6274.
  • 2FISCHER D, MUKRASCH M D, BIERNAT J, et al. Con- forrnational changes specific for pseudophosphorylation at ser- ine 262 selectively impair binding of tau to microtubules[J]. Biochemistry, 2009, 48(42): 10047-10055.
  • 3IIJIMA K, GATT A, IIJIMA-ANDO K. Tau Ser262 phos- phorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease[J]. Hum Mol Genet, 2010, 19(15): 2947-2957.
  • 4GONG C X, IQBAL K. Hyperphosphorylation of microtu- bule-associated protein tau: a promising therapeutic target for Alzheimer disease[J]. Curt Med Chem, 2008, 15(23) : 2321- 2328.
  • 5FEUILLETTE S, MIGUEL L, FREBOURG T, et al. Dro- sophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphoryla- ted forms of the proteln[J]. J Neurochem, 2010, 113(4): 895-903.
  • 6WEN Y, PLANEL E, HERMAN M, etal. Interplay be- tween cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing[J]. J Neurosci, 2008, 28(10):2624-2632.
  • 7HU M, WARING J F, GOPALAKRISHNAN M, et al. Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)- induced tau phosphorylation in PC12 cells[J].J Neurochem, 2008, 106(3):1371-1377.
  • 8LEROY K, YILMAZ Z, BRION J P. Increased level of active GSK-3beta in Alzhelmer' s disease and accumulation in argy- rophilic grains and in neurones at different stages of neurofi- brillary degeneration[J]. Neuropathol Appl Neuroblol, 2007, 33(1) : 43-55.
  • 9TIMM T, MARX A, PANNEERSELVAM S, et al. Struc- ture and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein[J]. BMC Neurosei, 2008, 9 (Suppi 2) : S9.
  • 10ZHOU X W, TANILA H, PEI J J. Parallel increase in p70 kinase activation and tau phosphorylation (S262) with Abeta overproductlon[J]. FEBS Lett, 2008, 582(2) : 159-164.

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生物医学工程学杂志
2012年 第4期

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