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重组人促甲状腺激素在甲状腺疾病诊治中的应用 被引量：6

Utility of recombinant human thyrotropin in the management of thyroid diseases
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摘要 重组人TSH（rhTSH）于1998年在国外进入临床应用，其临床适应证由辅助DTC患者的随访检查和检测逐渐扩展到辅助131I清除手术后残留甲状腺组织。近期研究表明，rhTSH在辅助131I治疗DTC转移灶、辅助131I治疗非毒性结节性甲状腺肿、提高18F-FDGPET对甲状腺癌的诊断效能及对先天性甲状腺功能减退症的病因鉴别诊断等多方面亦有应用潜力。 Recombinant human TSH （rhTSH） was introduced into clinical practice in 1998. The initial clinical application of rhTSH in facilitating follow-up studies for patients with DTC has been extended into aiding 131I ablation for post-surgical thyroid remnant. Recent studies have revealed the potential of rhTSH in enhancing 131I uptake for metastatic DTC foci and non-toxic multi-nodular goiter （MNG） as well as in strengthening 18F-FDG PET scans for characterizing DTC lesions and helping differential diagnosis of con- genital hypothyroidism.
作者 关海霞 陆汉魁
机构地区 中国医科大学附属第一医院内分泌科、内分泌研究所、辽宁省内分泌疾病重点实验室 上海交通大学附属第六人民医院核医学科
出处 《中华核医学与分子影像杂志》 CSCD 北大核心 2012年第4期311-314,共4页 Chinese Journal of Nuclear Medicine and Molecular Imaging
基金 国家自然科学基金（30801120）
关键词 促甲状腺激素 重组 甲状腺疾病 发展趋势 Thyrotropin Recombinant Thyroid diseases Trends
分类号 R817.4 [医药卫生—影像医学与核医学] R581 [医药卫生—内分泌]
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参考文献27

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二级参考文献10

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共引文献5

同被引文献80

  • 1ZHURui-sen YUYong-li LUHan-kui LUOQuan-yong CHENLi-bo.Clinical study of 312 cases with matastatic differentiated thyroid cancer treated with large doses of ^(131)I[J].Chinese Medical Journal,2005(5):425-428. 被引量：10
  • 2I Molinaro E, Viola D, Passannanti P, et al. Recombinant human TSH(rhTSH) in 2009: new perspectives in diagnosis and therapy [J]. Q J Nucl Med Mol Imaging, 2009, 53(5 ) : 490-502.
  • 3Pacini F, Molinaro E, Castagna MG, et al. Ablation of thyroid residues with 30 mCi nI : a comparison in thyroid cancer patients prepared with recombinant human TSH or thyroid hormone with- drawal[J]. J Clin Endocrinol Metab, 2002, 87 (9) : 4063-4068.
  • 4Pacini F, Ladenson PW, Schlumberger M, et al. Radioiodine abla- tion of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an inter- national, randomized, controlled study[J]. J Clin Endocrinol Metab, 2006, 91(3): 926-932.
  • 5Schlumberger M, Ricard M, De Pouvourville G, et al. How the availability of recombinant human TSH has changed the manage- ment of patients who have thyroid cancer[J]. Nat Clin Pract En- docrinol Metab, 2007, 3(9): 641-650.
  • 6Hinscheid H, Lassmann M, Luster M, et al. Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation af- ter rhTSH or hormone withdrawal[J]. J Nucl Med, 2006, 47(4) : 648-654.
  • 7Tuttle RM, Brokhin M, Omry G, et al. Recombinant human TSH-as- sisted radioactive iodine remnant ablation achieves short-term clin- ical recurrence rates similar to those of traditional thyroid hormone withdrawal[J]. J Nucl Med, 2008, 49(5 ) : 764-770.
  • 8Zanotti-Fregonara P, Hindi6 E, Toubert ME, et al. What role for re- combinant human TSH in the treatment of metastatic thyroid can- cer?[J]. Eur J Nucl Med Mol Imaging, 2009, 36(6): 883-885.
  • 9Luster M, Lippi F, Jarzab B, et al. rhTSH-aided radioiodine abla- tion and treatment of differentiated thyroid carcinoma: a compre- hensive review[J]. Endocr Relat Cancer, 2005, 12( 1 ) : 49-64.
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引证文献6

二级引证文献1865

中华核医学与分子影像杂志
2012年 第4期

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