辐射对组织器官损伤的形态学机制

Effect of radiation on the morphological mechanism of tissue and organ damage

背景:放射性事故不断有报道,造成的损伤越来越受到广泛关注,这方面的研究也有了很大进展。目的:对国外放射性损伤近些年的进展作一综述。方法:应用计算机检索CNKI和PubMed数据库中2000-01/2010-12关于放射性损伤的文章,在标题和摘要中以"放射性损伤"或"radiationinjury"为检索词进行检索。选择文章内容与放射损伤有关者,初检得到150篇文献,根据纳入标准选择关于放射损伤62篇文献进行综述。结果与结论:放射对神经系统亦有较大损害,可引起周围神经病、放射性脊髓病和其他神经损伤,对正常组织的损伤是引起炎症,随之胶原纤维增生、沉积、导致纤维化,脏器失去功能。

BACKGROUND： As the continuing reports of radioactive accidents, the damage caused by radiation has been attracted more and more attention. Research on the radiation has also been got significant progress. OBJECTIVE： To summarize the investigative situation and progression about radiation injury at abroad. METHODS： A computer research on CNKI database and PubMed database （2000-01/2010-12） was preformed to search the articles about radiation injury. The key word was ＂radiation injury＂. The articles related to radiation injury were selected. There were 150 articles after the initial survey. Then 62 articles related to radiation injury were included according to the inclusion criteria. RESULTS AND CONCLUSION： Radiation can also cause a great injury on nervous system, it can cause peripheral neuropathy, radiation spinal cord disease and other nerve injury. The damage to the normal tissue is inflammation, followed by is the proliferation of collagen fibers, deposition, fibrosis, and finally, loss of organ function.