维拉帕米对腹腔镜胆囊切除术氧化应激反应的影响

The impact of verapamil on oxidative stress reaction in laparoscopic cholecystectomy

目的:探讨术前静脉注射维拉帕米对腹腔镜胆囊切除术(LC)患者氧化应激反应的影响。方法:收集2007年1月至2008年10月广东省深圳市人民医院收治的30例行择期LC的慢性胆囊炎并胆囊结石患者的临床资料,将患者随机分为对照组和维拉帕米组,每组15例。分别测定两组患者术前(T1)、手术气腹结束即刻(T2)及术后24 h(T3)血清ALT、AST和丙二醛(MDA)的浓度。结果:与T1时相点比较,两组患者T2、T3时相点ALT和AST值均增高(P<0.05),维拉帕米组患者T2、T3时相点ALT和AST值增高幅度明显低于对照组(P<0.01);与T1时相点比较,对照组患者T2、T3时相点MDA值增高显著(P<0.05),维拉帕米组患者T2、T3时相点MDA值明显低于对照组(P<0.01)。结论:术前静脉注射维拉帕米能有效减小气腹带来的氧化应激反应,有效保护肝脏等脏器的功能。

Objective： To evaluate the impact of verapamil on oxidative stress reaction in patiens undergoing laparoseopic cholecystectomy （LC）. Methods：Between January 2007 and October 2008,30 patients with chronic cholecystitis and gallstone undergoing elective LC in Shenzhen People＇s Hospital of Guangdong province were randomly divided into control and verapamil groups （n = 15 each）. The concentrations of serum ALT, AST and malondialdehyde （ MDA ） at the time spots of （ T1 ） before surgery, （ ＂1＂2 ） after surgery and （ T3 ） 24h after surgery were determined in both two groups, respectively. Results：In both two groups, the ALT and AST values were increased at T2 and T3 time spots as compared with those at T1 （ P 〈 0.05 ）. Notably, the increased ALT and AST values at T2 and T3 in verapamil group were much lower than those in control group （P 〈 0.01 ）. The MDA value at T2 and T3 was significantly higher in control group as compared with that at T1 （ P 〈 0.05 ）, and the MDA value at T2 and T3 in verapamil group was obviously lower than that in control group （ P 〈 0.01 ）. Conclusion： The preoperative intravenous injection of verapamil could effectively reduce oxidative stress caused by pneumoperitoneum and protect the functions of liver.