富血小板纤维蛋白联合自固化型磷酸钙人工骨修复颌骨缺损

Platelet-rich fibrin combined with self-setting calcium phosphate cement for repairing jaw defects

背景:Choukroun富血小板纤维蛋白与自固化型磷酸钙人工骨都具有促进骨缺损修复的能力,但单独应用均有其不足,两种材料结合使用是否会达到理想效果?目的:观察Choukroun富血小板纤维蛋白联合自固化型磷酸钙人工骨在颌骨缺损修复中的作用。方法:将40例颌骨缺损患者随机分组:实验组缺损骨腔用Choukroun富血小板纤维蛋白联合自固化型磷酸钙人工骨充填,对照组缺损骨腔只充填自固化型磷酸钙人工骨。结果与结论:实验组治疗后1个月颌骨缺损区与周围颌骨有分界,有新骨开始形成;治疗后3个月,新骨与周围颌骨间的界限模糊不清,缺损区骨密度开始增加,有大量骨小梁形成;治疗后6个月缺损区与周围正常骨界限不清,开始出现正常骨质形态。对照组治疗后6个月新生骨与周围正常骨之间有明显界限,且缺损区骨腔内骨密度均低于同期实验组骨缺损区骨密度(P<0.05)。表明Choukroun富血小板纤维蛋白联合自固化型磷酸钙人工骨治疗颌骨缺损可明显促进骨组织生长。

BACKGROUND： Choukroun＇s platelet-rich fibrin （PRF） and self-setting calcium phosphate cement （CPC） can enhance the repair of bone defects, but either one has its limitation in clinical application. Whether the combination of the two materials can achieve a better effect remains unclear. OBJECTIVE： To investigate the effect of PRF combined with CPC on jaw defect repair. METHODS： Totally 40 patients were divided into two groups randomly. The experimental group （n=20） was filled with the combination of PRF and CPC, while the control group （n=20） was filled with CPC only. RESULTS AND CONCLUSION： In the experimental group, there was a boundary between jaw bone defect area and the surrounding jaw bone tissues, and new bone formed after treatment for 1 month. After 3 months of treatment, the boundaries between bone defect area and the surrounding normal jaw bone tissues were blurred, besides, bone mineral density in bone defect area began to increase and a large number of trabecular bone formed. After 6 months of treatment, the boundaries between the defect area and surrounding normal bone were unclear, and normal bone morphology appeared. In the control group after 6 months of treatment, the boundaries between new bone and the surrounding normal bone were marked, and bone density in the bone cavity of defects area was lower than that in the experimental group at the same period （P 〈 0.05）. These findings suggest that the combination of Choukroun＇s PRF and CPC can obviously promote bone growth in patients with jaw defects.