生物医学材料肝素涂层技术的应用及进展

Application and progress of heparin-coated technology in biomedical materials

背景:肝素涂层技术是近年来生物医学材料研究的一个活跃领域,其中涂层方法、涂层模式及涂层材料都有了很大进展。目的:对肝素固定中的肝素活性基团保护及不同固定方法、材料对应的不同固定模式进行了综述。方法:应用计算机检索CNKI、PubMed和美国专利数据库中关于生物医学材料肝素涂层技术的文章,在标题和摘要中以"肝素;涂层技术;固定方法;医学材料;抗凝活性"或"Heparin,coating technology,bond method,medical materials,anticoagulation activity"为检索词进行检索。选择文章内容与肝素涂层技术有关者,同一领域文献则选择近期发表或发表在权威杂志文章。初检得到161篇文献,根据纳入标准选择关于肝素涂层技术的29篇文献进行综述。结果与结论:肝素涂层技术通过对生物医学材料表面预改性,模拟了血管内皮细胞表面的抗凝机理,改善了生物医学材料表面的生物相容性和抗凝活性。提高肝素固定的稳定性、固定量,最大程度保留和提高固定到生物材料表面的肝素活性,将使肝素涂层技术得到更进一步的发展和应用。

BACKGROUND： For the past few years, the application of heparin coating technology is an active field in biomedical materials. Coating methods, coating models and coating materials are in great development. OBJECTIVE： To summarize the investigative situation and progression about different coating models in accordance with different methods and protection of heparin active groups. METHODS： A computer-based research was performed in CNKI database, PubMed database and US patent database to search the related articles about the application of heparin coating technology in biomedical materials. The key words were ＂heparin, coating technology, bond method, medical materials, anticoagulation activity＂ in Chinese and English. The articles related to the heparin coating technology were selected, and articles in the same field that published recently or in authorized journals were preferred. There were 161 articles after the initial survey. Then 29 articles related to heparin coating technology were involved according to the inclusion criteria. RESULTS AND CONCLUSION： Heparin coating technology can simulate the anticoagulant mechanism of vascular endothelial cells, and improve the biocompatibility and anticoagulation activity through modification of biomedical materials surface. Heparin coating technology will make great development and application by increasing the stability and quantity of bonded heparin and retaining heparin activity on biomaterial surface.