236例药品不良反应报告分析

Analysis of 236 Cases with Adverse Drug Reaction

目的了解本院药品不良反应(ADR)发生情况,促进临床合理用药。方法采用回顾性方法,对本院2009～2011年成功上报省中心的236例ADR报告分别从药品种类、给药途径、引发ADR前10位的药品、ADR累及的器官或系统及临床表现等方面进行统计、分析。结果 ADR涉及药品104种,抗菌药物和中药制剂的ADR报告例数居第1、第2位;静脉滴注药物引发的ADR占94.49%;ADR发生率最高的是左氧氟沙星注射剂;皮肤及附件损害为主,占52.97%。结论应重视ADR监测,合理使用抗菌药物和中药制剂,减少或避免ADR重复的发生。

Objective To understand features of ADR in Conghua Central hospital, so as to promote rational clinical drug application. Methods The drug categories, routes of administration, the top 10 ADR-indueed drugs, failed organs and clinical manifestation of 236 ADR cases that successfully reported to Center for ADR monitoring of Guangdong in the hospital in 2009 -2011 were retrospectively analyzed. Results ADRs were mainly caused by 104 kinds of drugs. Antibacterial and the traditional Chinese medicine injectable preparation dominated the first place and the second place respectively on the list of ADR report cases. 94.49% of the ADR cases was induced by IV drop drugs. Levofloxacin injection has the highest incidence rate of ADR. Skin and its appendages impairment cases took the largest percentage at 52.97%. Conclusion We should pay more attention to the ADR monitoring, the antibacterial and the traditional Chinese medicine injectable should be rationally used, so as to reduce the occurrence of ADR.