人膝骨关节炎滑膜血管活性肠肽的表达及其与疼痛的关系

THE EXPRESSION OF VASOACTIVE INTESTINAL PEPTIDE IN HUMAN KNEE OSTEOART-HRITIS SYNOVIUM AND THE relationship BETWEEN VASOACTIVE INTESTINAL PEP-TIDE AND KNEE OSTEOARTHRITIS PAIN

目的:研究血管活性肠肽(vasoactive intestinal peptide,VIP)在人膝骨关节炎滑膜中的表达特点,并探讨其与患者膝关节疼痛程度之间的相关性。方法:采集18例骨关节炎患者膝关节滑膜,根据术前视觉模拟疼痛评分(visual analogue scale,VAS)分为轻中度疼痛组(M组)和重度疼痛组(S组),7例外伤病人滑膜作为对照组(C组)。检测患者和正常人滑膜内VIP的含量和位置。结果:正常膝关节和骨关节炎膝关节滑膜均表达VIP,滑膜衬里层和衬里下层的表达无显著性差异(P>0.05)。轻中度疼痛组(M组)滑膜VIP表达高于对照组(C组)和重度疼痛组(S组)(P<0.05)。VIP与疼痛无线性相关。结论:VIP可能在人膝骨关节炎中参与轻度致痛作用,而在重度疼痛中不起主要作用。

Objective： To detect the vasoactive intestinal peptide （VIP） expression in ht, man knee osteoarth- ritis synovium and the relationship between VIP and knee osteoarthritic pain. Methods： Osteoarthritic knee synovium tissues from 18 patients were collected. According to visual analogue scale （VAS）, the synovium tissues were divided into two groups： mild to moderate pain group （M group） and severe pain group （S group）. Normal knee synoviurn tissues l^om 7 patients with trauma were collected as control （C group）. The VIP expression and location were observed. Results： VIP was expressed in both normal and osteoarthritis knee joint synovium, and there are no difference in VIP expression between synovial lining and sublining layer （P 〉 0.05）. The VIP expressed in mild to moderate pain group （M group） was higher than that in the control group （C group） and severe pain group （S group） （P 〈 0.05）. VIP expression in synovial has no linear correlation with pain scores. Conclusion： VIP involves in mild to moderate pain in human knee osteoarthritis, but may not play a major role in the severe pain.