类风湿性关节炎与系统性红斑狼疮重叠综合征一例报告及文献复习

Clinical Manifestations of Coexistent Rheumatoid Arthritis and Systemic Lupus Erythematosus(Rhupus syndrome)

目的:探讨类风湿关节炎(RA)与系统性红斑狼疮(SLE)重叠综合征(Rhupus综合征)的临床表现及治疗方法,以期提高对本病的认识。方法:对1例类风湿关节炎(RA)与系统性红斑狼疮(SLE)重叠的Rhupus综合征患者的病例资料进行分析。结果:本例患者为中年女性,以RA为首发表现,8年后出现SLE特征性表现。就诊时关节症状较严重,出现多关节变形。本例患者肾脏损害重,糖皮质激素联合甲氨喋呤治疗有效。结论:Rhupus综合征在临床上罕见,加强特异性抗体检查,可减少误诊漏诊,早期正确诊断,积极治疗,对于改善患者预后具有重要意义。

Objective： To investigate the clinical manifestations and therapeutic approach of coexistent rheumatoid arthritis （RA） and systemic lupus erythematosus （SLE） （Rhupus syndrome）. Methods： Clinical data from a patient with Rhupus syndrome were ana- lyzed combined with literature review. Results： The patient was a middle-aged female, who had presented with features of RA and devel- oped features of SLE 8 years later. The patient had severe renal dysfunction and showed part remission with glucocorticosteroids and methotrexate therapy. Conclusions： Rhupus syndrome is a rare condition sharing features of RA and SLE. Early diagnosis and aggressive treatment might improve the prognosis.