术前血清CEA水平与非小细胞肺癌预后关系的Meta分析

Prognostic Significance of Preoperative Serum Carcinoembryonic Antigen in Non-Small Cell Lung Cancer:A Meta-Analysis

目的:采用Meta分析的方法评估术前血清CEA(carcinoembryonic antigen)高水平与非小细胞肺癌(NSCLC)预后之间的关系。方法:从PubMed、EMBASE数据库中查找血清CEA水平与NSCLC预后关系的相关研究,收集每篇文献的相对危险比(hazard ratio,HR)以及95%可信区间(95%C1),应用Meta分析Dersimonian-Laird模型对文献进行定量综合分析。结果:共入选13篇文献,累计研究CEA与NSCLC预后关系的病例3505例。对入选13篇文献进行一致性检验,文献具有异质性(Q=2201.96,P=0.000),合并相对危险比HR为2.33(95%可信区间:2.03-2.68,P=0.000)。结论:术前血清CEA高浓度水平可能是NSCLC的不良预后因素。

Objective： To evaluate the relationship between elevated preoperative serum CEA and the prognosis of non-small cell lung cancer by a meta-analysis. Methods： Searched Articles on the correlation of elevated concentration of preoperative serum CEA expression with the prognosis of non-small cell lung cancer from Medline and Embase,extracted the ItR （hazard ratio）and 95%CI （confidence interval）in every article.Analyzed the results of 13 studies by Dersimonian-Laird method. Results： 3505 patients of the relation between the level of CEA and NSCLC prognosis researched from 13 studies were included. The analysis for homogeneity（Q statistics test）showed that all eligible studies were with heterogeneity （Q=2201.96,P=0.000）. The combined HR was 2.33 and 95%CI was 2.03-2.68, P=0.000. Conclusion： High concentrations of Preoperative CEA may be the poor prognosis factor of non-small cell lung cancer.