极小胚胎样干细胞与神经再生

Very Small Embryonic-Like Stem Cells and Neural Regeneration

再生医学的目的是为了减轻组织损伤所致的不可逆性功能损害,多种类型的干细胞可促进神经再生,发挥治疗作用。近来,在骨髓和其他组织中发现了一种数量极少的极小胚胎样干细胞(VSELs),其分子标志为Oct-4+CXCR4+SSEA-1+Sca-1+lin-CD45-,它们可动员到外周血中。在给予动员剂或组织损伤等应激情况下可向损伤区迁移,现在认为它是高度迁移的外胚层/生殖系源性的干细胞群,具有多能干细胞特征,能分化为三个胚层细胞,综上所述,极小胚胎样干细胞可能通过促进神经再生修复中枢神经系统损伤。

The goal of regenerative medicine is to alleviate irreversible dysfimction caused by tissue damage. Multiple types of stem cells could promote neural regeneration and play a therapeutic role. Recently, we found a population of Oct-4＋CXCR4＋SSEA-I＋ Sca-l＋lin-CD45＋ very small embryonic like stem cells （VSELs） that can mobilize into peripheral blood. These cells mobilize to the damaged areas in emergency situations of tissue damage or administration of mobilization agents. Now that it is a high degree of migration of epiblast/germ line-derived stem cell populations. It has a pluripotent stem cell characteristics that could give rise to all three germ layers of cells. In conclusion, very small embryonic-like stem cells may promote neural regeneration and repair injury of central nervous system.